Pursuing human-centered, sustainable, and resilient production is shaping a future-oriented approach to manufacturing processes in the context of Industry 5.0. How can such production be implemented? For this purpose, this article analyses the effects of the developed Dresden Model of Adaptability (acronym: DreMoWabe) on the integration of holistic sustainability. The focus is on investigating the promotion of economic, environmental, and social sustainability goals in terms of the 17 Sustainable Development Goals and analyzing strategies to increase resilience to changing environmental conditions. A human-centered perspective is considered. The model proves to be a holistic approach that drives sustainable development of the production system through the comprehensive integration of human, technology, and organizational structures.